李宗夷(Tzong-Yi Lee) 副教授 (留辦時間) 

  辦公室/電話:R3312C / 03-4638800#3007
  實驗室:      1706C  、個人網頁
  實驗室分機: 2367轉7063
  最高學歷:   國立交通大學 生物資訊與系統生物學博士
  Email:       francis@saturn.yzu.edu.tw

授過課程:
  • 資料結構
  • 線性代數
  • 生物資訊概論
  • 計算蛋白質體學專題
  • 生醫資料庫設計與實作

研究領域
  • 生醫資料庫、資料探勘與程式設計
  • 生物晶片、癌症標記與調控網路分析
  • 計算蛋白質體學與系統生物學
  • 次世代定序資料分析(Metagenomics and metatranscriptomics)
  • 機器學習與最佳化計算

主要經歷
  • 元智大學資訊工程系 助理教授 2009/08 ~ 2012/07
  • 元智大學資訊工程系 副教授 2012/08 ~

期刊論文:
  • Cheng-Tsung Lu†, Kai-Yao Huang†, Min-Gang Su† († joint first authorship), Tzong-Yi Lee*, Neil Arvin Bretaña, Wen-Chi Chang, Yi-Ju Chen, Yu-Ju Chen, and Hsien-Da Huang*, 2013, "dbPTM 3.0: an informative resource for investigating substrate site specificity and functional association of protein post-translational modifications," Nucleic Acids Research, 41:D295-305. (SCI, 2011 IF: 8.026; 26/289 in BIOCHEMISTRY & MOLECULAR BIOLOGY)

  • Tzu-Hao Chang, Li-Ching Wu, Tzong-Yi Lee, Shu-Pin Chen, Hsien-Da Huang* and Jorng-Tzong Horng*, 2012, "EuLoc: a web-server for accurately predict protein subcellular localization in eukaryotes by incorporating various features of sequence segments into the general form of Chou's PseAAC," Journal of Computer-Aided Molecular Design, (Accepted). (SCI, 2011 IF:3.386; 8/99 in COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS)

  • Tzong-Yi Lee*, Yi-Ju Chen, Cheng-Tsung Lu, Wei-Chieh Ching, Yu-Chuan Teng, Hsien-Da Huang and Yu-Ju Chen*, 2012, "dbSNO: a database of cysteine S-Nitrosylation," Bioinformatics, 28(17):2293-5. (SCI, 2011 IF:5.468; 1/47 in MATHEMATICAL & COMPUTATIONAL BIOLOGY)

  • Neil Arvin Bretaña, Cheng-Tsung Lu, Chiu-Yun Chiang, Min-Gang Su, Kai-Yao Huang, Tzong-Yi Lee* and Shun-Long Weng, 2012, "Identifying Protein Phosphorylation Sites with Kinase Substrate Specificity on Human Viruses," PLoS ONE, 7(7): e40694. (SCI, 2011 IF:4.092; 12/84 in BIOLOGY)

  • Tzong-Yi Lee*, Wen-Chi Chang*, Justin BK Hsu, Tzu-Hao Chang and Dray-Ming Shien, 2012, January "GPMiner: an integrated system for mining combinatorial cis-regulatory elements in mammalian gene group," BMC Genomics, 13(Suppl 1):S3. (SCI, 2011 IF: 4.073; 26/157 in BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

  • Cheng-Tsung Lu, Neil Arvin Bretaña, Tzu-Hsiu Cheng, and Tzong-Yi Lee*, 2011, "Carboxylator: incorporating solvent-accessible surface area for identifying protein carboxylation sites," Journal of Computer-Aided Molecular Design, 25(10):987-95. (SCI, 2010 IF:3.374; 4/97 in COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS)

  • Justin Bo-Kai Hsu, Neil Arvin Bretaña, Tzong-Yi Lee* and Hsien-Da Huang*, 2011, "Incorporating evolutionary information and functional domains for identifying RNA splicing factors," PLoS ONE, 6(11): e27567. (SCI, 2010 IF:4.411; 12/85 in BIOLOGY)

  • Tzong-Yi Lee*, Cheng-Tsung Lu, Shu-An Chen, Neil Arvin Bretaña, Tzu-Hsiu Cheng, Min-Gang Su, and Kai-Yao Huang, 2011, "Investigation and identification of protein γ-glutamyl carboxylation sites," BMC Bioinformatics, 12 Suppl 11, S10. (SCI, 2010 IF: 3.028; 4/37 in MATHEMATICAL & COMPUTATIONAL BIOLOGY)

  • C.H. Chien, Y.M. Sun, W.C. Chang, P.Y. Chiang-Hsieh, Tzong-Yi Lee, W.C. Tsai, J.T. Horng, A.P. Tsou*, H.D. Huang*, 2011, "Identifying transcriptional start sites of human microRNAs based on high-throughput sequencing data," Nucleic Acids Research, 39(21):9345-9356. (SCI, 2011 IF: 8.026; 26/289 in BIOCHEMISTRY & MOLECULAR BIOLOGY)

  • Justin Bo-Kai Hsu, Chih-Min Chiu, Sheng-Da Hsu, Wei-Yun Huang, Chia-Hung Chien, Tzong-Yi Lee and Hsien-Da Huang*, 2011, "miRTar: an integrated system for identifying miRNA-target interactions in Human," BMC Bioinformatics, 12:300. (SCI, 2010 IF: 3.028; 4/37 in MATHEMATICAL & COMPUTATIONAL BIOLOGY)

  • Tzong-Yi Lee*, Yi-Ju Chen, Tsung-Cheng Lu, Hsien-Da Huang and Yu-Ju Chen*, 2011, "SNOSite: exploiting maximal dependence decomposition to identify cysteine S-nitrosylation with substrate site specificity," PLoS ONE, 6(7): e21849. (SCI, 2010 IF:4.411; 12/85 in BIOLOGY)

  • Tzong-Yi Lee*, Neil ARVIN Bretana, and Cheng-Tsung Lu, 2011, "PlantPhos: using Maximal Dependence Decomposition to Identify Plant Phosphorylation Sites with Substrate Site Specificity," BMC Bioinformatics, 12:261. (SCI, 2010 IF: 3.028; 4/37 in MATHEMATICAL & COMPUTATIONAL BIOLOGY)

  • Tzong-Yi Lee*, Zong-Qing Lin, Sheng-Jen Hsieh, Neil Arvin Bretaña, and Cheng-Tsung Lu, 2011, "Exploiting maximal dependence decomposition to identify conserved motifs from a group of aligned signal sequences," Bioinformatics, 27(13): 1780-1787. (SCI, 2011 IF:5.468; 1/47 in MATHEMATICAL & COMPUTATIONAL BIOLOGY)

  • Shu-An Chen, Yu-Yen Ou, Tzong-Yi Lee and M. Michael Gromiha*, 2011, June "Prediction of transporter targets using efficient RBF networks with PSSM profiles and biochemical properties," Bioinformatics, 27(15):2062-7. (SCI, 2011 IF:5.468; 1/47 in MATHEMATICAL & COMPUTATIONAL BIOLOGY)

  • Tzong-Yi Lee*, Shu-An Chen, Hsin-Yi Hung, and Yu-Yen Ou, 2011, "Incorporating distant sequence features and radial basis function network to identify ubiquitin conjugation sites," PLoS ONE, 6(3): e17331. (SCI, 2010 IF:4.411; 12/85 in BIOLOGY)

  • Tzong-Yi Lee, Justin Bo-Kai Hsu, Wen-Chi Chang, and Hsien-Da Huang* , 2011, "RegPhos: a system to explore the protein kinase-substrate phosphorylation network in humans," Nucleic Acids Research, Vol. 39, D777-D787. (SCI, 2011 IF: 8.026; 26/289 in BIOCHEMISTRY & MOLECULAR BIOLOGY)

  • Shu-An Chen†, Tzong-Yi Lee† († joint first authorship), and Yu-Yen Ou*, 2010, "Incorporating significant amino acid pairs to identify O-linked glycosylation sites on transmembrane proteins and non-transmembrane proteins," BMC Bioinformatics, 11:536. (SCI, 2010 IF: 3.028; 4/37 in MATHEMATICAL & COMPUTATIONAL BIOLOGY)

  • Tzong-Yi Lee, Justin Bo-Kai Hsu, Feng-Mao Lin, Wen-Chi Chang, Po-Chiang Hsu, and Hsien-Da Huang, 2010, "N-Ace: using solvent accessibility and physicochemical properties to identify protein N-Acetylation sites," Journal of Computational Chemistry, Vol. 31 (15), 2759-2771. (SCI, 2010 IF: 4.050; 27/144 in CHEMISTRY, MULTIDISCIPLINARY)

  • D.M. Shien†, Tzong-Yi Lee† († joint first authorship), W.C. Chang, J.B.K. Hsu, J.T. Horng, P.C. Hsu, T.Y. Wang and H.D. Huang*, 2009, Jul 15 "Incorporating Structural Characteristics for Identification of Protein Methylation Sites," Journal of Computational Chemistry, Vol. 30, No. 9, pp.1532-1543. (SCI, 2010 IF: 4.050; 27/144 in CHEMISTRY, MULTIDISCIPLINARY)

  • W.C. Chang†, Tzong-Yi Lee† († joint first authorship), D.M. Shien, J. B.K. Hsu, P.C. Hsu, T.Y. Wang, J.T. Horng, H.D. Huang* and R.L. Pan*, 2009, Nov 30 "Incorporating support vector machine for identifying protein tyrosine sulfation sites," Journal of Computational Chemistry, . (SCI, 2010 IF: 4.050; 27/144 in CHEMISTRY, MULTIDISCIPLINARY)

  • Tzong-Yi Lee, J.B.K. Hsu, W.C. Chang, T.Y. Wang, P.C. Hsu, and H.D. Huang*, 2009, "A Comprehensive Resource for Integrating and Displaying Protein Post-Translational Modifications," BMC Research Notes, 2(1):111.

  • W.C. Chang, Tzong-Yi Lee, H.D. Huang*, H.Y. Huang, R.L. Pan*, 2008, "PlantPAN: Plant Promoter Analysis Navigator, for identifying combinatorial cis-regulatory elements with distance constraint in plant gene group," BMC Genomics, 9:561. (SCI, 2010 IF: 4.206; 24/160 in BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

  • Y.H. Wong†, Tzong-Yi Lee† († joint first authorship), H.K. Liang, C.M. Huang, Y.H. Yang, C.H. Chu, H.D. Huang* , M.T. Ko, and J.K. Hwang, 2007, "KinasePhos 2.0: a web server for identifying protein kinase-specific phosphorylation sites based on sequences and coupling patterns," Nucleic Acids Research, Vol 35, W588-594. (SCI, 2010 IF: 7.836; 30/286 in BIOCHEMISTRY & MOLECULAR BIOLOGY)

  • Tzong-Yi Lee, J.T. Horng, H.F. Juan, H.D. Huang, L.C. Wu, and F.M. Lin, 2006, "An agent-based system to discover protein-protein interactions, identify protein complexes and proteins with multiple peptide mass fingerprints," Journal of Computational Chemistry, Vol. 27, No. 9, 1020-32. (SCI, 2010 IF: 4.050; 27/144 in CHEMISTRY, MULTIDISCIPLINARY)

  • Tzong-Yi Lee, H.D. Huang*, J.H. Hung, Y.S. Yang, and T.H. Wang*, 2006, "dbPTM: An information repository of protein post-translational modification," Nucleic Acids Research, Vol. 34, D622-D627. (SCI, 2010 IF: 7.836; 30/286 in BIOCHEMISTRY & MOLECULAR BIOLOGY)

  • J.H. Hung†, H.D. Huang†,* († joint first authorship), and Tzong-Yi Lee, 2006, "ProKware: an integrated software for presenting protein structural properties in protein tertiary structures," Nucleic Acids Research, Vol 34, W89-W94. (SCI, 2010 IF: 7.836; 30/286 in BIOCHEMISTRY & MOLECULAR BIOLOGY)

  • H.D. Huang*, Tzong-Yi Lee, S.W. Tseng, L.C. Wu, J.T. Horng, and A.P. Tsou, 2005, "Incorporating Hidden Markov Model for identifying protein kinase-specific phosphorylation sites," Journal of Computational Chemistry, Vol. 26, pp.1032-1041. (SCI, 2010 IF: 4.050; 27/144 in CHEMISTRY, MULTIDISCIPLINARY)

  • H.D. Huang, Tzong-Yi Lee, L.C. Wu, F.M. Lin, J.T. Horng, and A.P. Tsou, 2005, "MultiProtIdent: identifying proteins using database search and protein-protein interactions," Journal of Proteome Research, Vol. 4(3), 690-697. (SCI, 2010 IF: 5.460; 9/71 in BIOCHEMICAL RESEARCH METHODS)

  • H.D. Huang*, Tzong-Yi Lee, S.W. Tseng, and J.T. Horng, 2005, "KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites," Nucleic Acids Research, Vol. 33, W226-229. (SCI, 2010 IF: 7.836; 30/286 in BIOCHEMISTRY & MOLECULAR BIOLOGY)


研究計畫:
  • 結合生物資訊方法與蛋白質譜實驗研究大腸癌亞硝基化與一氧化氮訊息傳遞網路 (MOST 103-2221-E-155 -020 -MY3)

   8/1/2014-7/31/2017
  • 利用生物資訊方法與轉錄體生物晶片探究微生物群落、基因功能與代謝路徑(MOST 103-2633-E-155 -002)

   10/1/2014-9/30/2015
  • 蛋白質磷酸化網路於人類癌症之發現 (101-2628-E-155-002-MY2)

   8/1/2012-7/31/2014
  • 利用生物資訊方法辨識植物磷酸化位置與其催化激酶 (NSC 100-2221-E-155-079)

   8/1/2011-7/31/2012
  • 蛋白質後轉譯修飾調控網路之建構 (NSC 99-2320-B-155-001)

   2/1/2010-7/31/2011

建教合作計畫:
  • 應用生物資訊分析比較精子上泳試驗表現之基因表達譜 (103年度衛生福利部桃園醫院研究發展計畫-協同主持人) (衛生福利部 - 桃園醫院)

   1/1/2014-12/31/2014
專任教師

李宗夷

周志岳

林基成

林啟芳

林榮彬

姚修慎

范金鳳

翁資雅

張經略

陳勇志

陳淑媛

曾王道

游家牧

黃柏鈞

黃依賢

黃哲志

黃毅然

楊正仁

葉奕成

劉一宇

劉如生

歐昱言

蔡侑庭

賴國華

鍾添曜

合聘教師

王任瓚

兼任教師

李政緯

黃博俊

葉生正

榮譽退休教授

劉寶鈞

退休教師

黃朝章